Akta Oligopilot 100

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Item#: 29735
Tag: DNA Synthesizer

Description

The ÄKTA Oligopilot 100 is an automated synthesizer designed for the scalable production of DNA and RNA oligonucleotides. It is commonly used in research, process development, and small-scale manufacturing, offering high efficiency and precision across a broad synthesis range.

Key Features:

• Flow-Through Reactor Technology: Enables efficient coupling and reduced reagent consumption through continuous flow operation.
• Multiple Synthesis Capability: Allows sequential synthesis of up to seven different oligonucleotides with support for up to twelve different synthesis monomers.
• Efficient Reagent Use: Minimizes phosphoramidite consumption per coupling while maintaining high coupling efficiencies.
• Scalability: Easily scalable from development to production without requiring method re-optimization.
• Real-Time Monitoring: Includes built-in UV and conductivity detectors for continuous tracking of reaction progress.
• Software Integration: Controlled via UNICORN software for method creation, instrument control, and data evaluation with regulatory compliance features.

Specifications:

• Synthesis Scale: 50 µmol to 9 mmol
• Coupling Efficiency: >99% for DNA, >98% for RNA
• Cycle Time: 4.5 to 25 minutes per DNA synthesis cycle
• Reagent Stability: Up to two weeks within the system
• Dimensions: 450 mm (W) × 610 mm (H) × 480 mm (D)
• Weight: Approximately 63 kg
• Reactor Capacity: Supports up to 7 columns
• Monomer Ports: Standard 8, expandable to 12
• Pump Flow Rate: Dual pumps, up to 100 mL/min each
• Monitoring: Conductivity, UV-Vis (254–700 nm), and pressure
• Inert Atmosphere: Operates under nitrogen or argon for reagent protection

The ÄKTA Oligopilot 100 provides a reliable and efficient platform for high-quality oligonucleotide synthesis, combining precision, automation, and scalability to support demanding laboratory and production environments.